Effect of exercise training in rats exposed to chronic hypoxia: Application for Monge’s disease

Autor: José‐Luis Macarlupu, Dominique Marchant, Florine Jeton, Francisco Villafuerte, Jean‐Paul Richalet, Nicolas Voituron
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Physiological Reports, Vol 9, Iss 7, Pp n/a-n/a (2021)
Druh dokumentu: article
ISSN: 2051-817X
DOI: 10.14814/phy2.14750
Popis: Abstract Physical exercise may improve hematological conditions in high altitude dwellers suffering from Chronic Mountain Sickness (CMS), in reducing hemoglobin concentration. Therefore, the present study aimed to characterize the effects of 1‐month exercise training session in a model of rats exposed to chronic hypoxia. Four groups of male rats were studied: normoxic sedentary (NS, n = 8), normoxic training (NT, n = 8), hypoxic sedentary (HS, n = 8), and hypoxic training group (HT, n = 8). Hypoxic groups were exposed to hypobaric hypoxia for one month (PB =433 Torr). Training intensity was progressively increased from a running speed of 10.4 to 17.8 m/min. Chronic hypoxia led to an increase in hematocrit (HCT) associated with a decrease in plasma volume despite an increase in water intake. Training led to a reduction in HCT (p
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