Dynamic regulation of GDP binding to G proteins revealed by magnetic field-dependent NMR relaxation analyses

Autor: Yuki Toyama, Hanaho Kano, Yoko Mase, Mariko Yokogawa, Masanori Osawa, Ichio Shimada
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms14523
Popis: Heterotrimeric guanine-nucleotide-binding proteins (G proteins) act as molecular switches. Here the authors use NMR relaxation analyses, which reveal the dynamics of G protein alpha subunit binding to GDP on a microsecond timescale.
Databáze: Directory of Open Access Journals