Immunofibroblasts regulate LTα3 expression in tertiary lymphoid structures in a pathway dependent on ICOS/ICOSL interaction

Autor: Saba Nayar, Elena Pontarini, Joana Campos, Onorina Berardicurti, Charlotte G. Smith, Saba Asam, David H. Gardner, Serena Colafrancesco, Davide Lucchesi, Rachel Coleby, Ming-May Chung, Valentina Iannizzotto, Kelly Hunter, Simon J. Bowman, Gianluca Carlesso, Ronald Herbst, Helen M. McGettrick, Jeff Browning, Christopher D. Buckley, Benjamin A. Fisher, Michele Bombardieri, Francesca Barone
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-022-03344-6
Popis: The study suggests a link between ICOS-ICOSL signaling and LTa3 induction on T cells. LTa3 subsequently activates fibroblasts in the salivary gland, leading to formation of tertiary lymphoid tissues (TLS).
Databáze: Directory of Open Access Journals
Nepřihlášeným uživatelům se plný text nezobrazuje