An image processing technique for diagnosis of Alzheimer's disease
| Autor: | Massoud Mahmoudian, Soltan Ahmad Ebrahimi, Zahra - Kiani |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | Journal of Research in Medical Sciences, Vol 14, Iss 4, Pp 205-209 (2009) |
| Druh dokumentu: | article |
| ISSN: | 1735-1995 1735-7136 |
| Popis: | BACKGROUND: Patients with Alzheimer's disease (AD) reportedly hibit hypersensitivity to much diluted tropicam solution (0.005%), a M4 muscarinic receptor antagonist. Therefore aocular application of 0.005% tropicamide ma be useful for screening dementia. The aim of this study was to simplify the pupil response test by using a new image analyzing system, which consists of a cheap, simple, and easy to use web-camera and a computer.METHODS: Intraocular tropicamide of 0.005% concentration was administered in 3 groups: Alzheimer's disease patients (n = 8, average age = 76 ± 5), non-Alzheimer's disease elderly (n = 6, average age = 65 ± 7), and young subjects (n = 8, average age = 28 ± 5). Every 5 minutes for 60 minutes, image of the eye's shape were taken, and the diameter of the pupils was measured.RESULTS: The results showed that differences in pupil dilation rate between Alzheimer's disease and non-Alzheimer's disease subjects were statistically significant. ROC analysis showed that after 35 minutes the sensitivity and specificity of the test were 100%.CONCLUSIONS: Based on our results, we concluded that this recording system might be an appropriate and reliable tool for pupil response diagnosis test of Alzheimer's disease.KEYWORDS: Alzheimer’s Disease, Tropicamide, Pupil. |
| Databáze: | Directory of Open Access Journals |
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