Impact of the polymer backbone chemistry on interactions of amino-acid-derived zwitterionic polymers with cells

Autor: Meike N. Leiske, Bruno G. De Geest, Richard Hoogenboom
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Bioactive Materials, Vol 24, Iss , Pp 524-534 (2023)
Druh dokumentu: article
ISSN: 2452-199X
DOI: 10.1016/j.bioactmat.2023.01.005
Popis: Zwitterionic polymers are known to interact with cells and have been shown to reveal cancer cell specificity. In this work, the importance of the chemistry of the polymer backbone for the cellular specificity of amino-acid-derived polyzwitterions is demonstrated. A series of glutamic acid (Glu)-based vinyl monomers (i.e., an acrylate, a methacrylate, an acrylamide, and a methacrylamide) were prepared and used for reversible addition-fragmentation chain-transfer (RAFT) polymerisation, yielding defined polymers with narrow size distribution (Ð
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