| Popis: |
Antimicrobial resistance (AMR) has been recorded as a fast-growing One Health challenge globally. The major driver of AMR is the inappropriate use of antibiotics in humans and animals. A substantial volume of antimicrobials is consumed by the animal industry for the treatment of Escherichia coli (E. coli) infections, which is a challenge; therefore, the understanding of AMR in animals is critical in solving this rising One Health problem. This study assessed the resistance level of some critically important antibiotics to E. coli bacteria isolates from cattle fecal samples. A total of twenty-eight composite (n = 5) fecal samples were collected from farms in four different Local Government Areas (LGAs) within Ibadan: Akinyele LGA:7, Ibadan north LGA:12, Ido LGA:4, and Lagelu LGA:5. Standard microbiological methods were used for isolation, antibiotic sensitivity tests (ASTs), and ESBL production. A total of 22 (78.6%) E. coli isolates were recovered, and the results showed resistance to critically important antibiotics in ascending order; streptomycin (0.00%), meropenem (0.00%), gentamicin (4.55%), ceftazidime (18.8%), sulphamethazole (22.73%), cefotaxime (54.55%), ampicillin (63.64%), pefloxacin (81.82%), and amoxicillin–clavulanate (100%). Of the 22 positive E. coli isolates, 8 (36.4%) were ESBL-producing and 17 (60.7%) were multidrug-resistant. ESBL enzymes share the ability to hydrolyze third-generation Cephalosporin, and this makes ESBL-producing E. coli exhibit resistance to antibiotics (especially Cephalosporins). The results show the possibility of AMR becoming a looming pandemic globally. The presence of multidrug-resistant ESBL-producing E. coli in cattle in Ibadan was established. Resistance to third-generation Cephalosporin antibiotics is of public health significance. Ensuring antimicrobial stewardship and prescription-based medication, alternative therapies to antibiotics, and the adoption of a collaborative approach are measures to preventing an AMR pandemic. |
