| Autor: |
Rebecca D. Kehm, E. Jane Walter, Ana Pereira, Melissa L. White, Sabine Oskar, Karin B. Michels, John A. Shepherd, Lothar Lilge, Mary Beth Terry |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-022-17800-0 |
| Popis: |
Abstract This study compared different approaches to measuring breast density and breast tissue composition (BTC) in adolescent girls (n = 42, aged 14–16 years) and their mothers (n = 39, aged 36–61 years) from a cohort in Santiago, Chile. Optical spectroscopy (OS) was used to measure collagen, water, and lipid concentrations, which were combined into a percent breast density index (%BDI). A clinical dual-energy X-ray absorptiometry (DXA) system calibrated to measure breast density provided percent fibroglandular volume (%FGV) from manually delineated images. After digitizing mammogram films, the percent mammographic breast density (%MBD) was measured using computer-assisted software. Partial correlation coefficients (r partial) were used to evaluate associations between breast density measures and BTC from these three different measurement approaches, adjusting for age and body mass index. %BDI from OS was associated with %FGV from DXA in adolescent girls (r partial = 0.46, p-value = 0.003), but not in mothers (r partial = 0.17, p-value = 0.32). In mothers, %FGV from DXA was associated with %MBD from mammograms (r partial = 0.60, p-value |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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