Identification of diagnostic markers of pancreatic ductal adenocarcinoma using transcriptomic tumour and blood sample data

Autor: Aristeidis Sionakidis, Panagiotis Nikolaos Lalagkas, Andigoni Malousi, Ioannis S. Vizirianakis
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Clinical and Translational Discovery, Vol 3, Iss 5, Pp n/a-n/a (2023)
Druh dokumentu: article
ISSN: 2768-0622
DOI: 10.1002/ctd2.248
Popis: Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is the most frequently diagnosed form of pancreatic cancer worldwide. PDAC is associated with a poor survival rate mainly due to the disease being usually diagnosed at late stages. Methods Publicly available gene expression data from 10 studies with tumour tissue (448 samples) and/or blood samples (128 samples) from PDAC patients were pooled together and analyzed for the identification of stage‐specific and global diagnostic markers using differential gene expression analysis. The list of statistically significant (padj
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