Questionable robustness in the findings of a meta-analysis

Autor:	Borja Somovilla Del Saz
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	meta-analysis all-cause mortality cardiac-related mortality covid vaccines covid-19 Immunologic diseases. Allergy RC581-607 Therapeutics. Pharmacology RM1-950
Zdroj:	Human Vaccines & Immunotherapeutics, Vol 19, Iss 2 (2023)
Druh dokumentu:	article
ISSN:	2164-5515 2164-554X 21645515
DOI:	10.1080/21645515.2023.2253959
Popis:	Marchand and colleagues conducted a meta-analysis examining COVID vaccine effects on all-cause and cardiac-related mortality. Findings aligned with previous research, showing no association with all-cause mortality. However, cardiac-related mortality exhibited a 6% increase post-vaccination. Concerns arise from reliance on a non-peer-reviewed study (Ladapo, 2022) influencing results significantly. Sensitivity analyses were lacking, undermining result robustness, particularly in gender-specific outcomes. Adherence to PRISMA guidelines for transparency and thoroughness could strengthen conclusions. This study underscores vaccine safety scrutiny, yet the influence of biased sources and absence of sensitivity testing warrant careful consideration.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/982ab4cba6d64aa0b58ecf9b2266d0f0 Zobrazit plný text záznamu View record in DOAJ