| Autor: |
Ting Zhang, Carsten Künne, Dong Ding, Stefan Günther, Xinyue Guo, Yonggang Zhou, Xuejun Yuan, Thomas Braun |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-022-34577-y |
| Popis: |
Suppression of transcription in S-phase is crucial to prevent genome instability. Zhang et al demonstrate that increase of H4K20me1 due to loss of Kmt5b cause genome instability in muscle stem cells, resulting in stem cell senescence but rhabdomyosarcoma formation when p53 is inactivated. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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