Comparison of E- cadherin and CD44 Marker Expression in Oral Lichen Planus, Oral Leukoplakia, and Oral Squamous Cell Carcinoma
| Autor: | Khadijeh Abdal, Samira Mostafazede, Nastaran Ghorbani, Mohammadreza Hafeziahmadi |
|---|---|
| Jazyk: | perština |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, Vol 30, Iss 5, Pp 24-31 (2022) |
| Druh dokumentu: | article |
| ISSN: | 1563-4728 2588-3135 |
| Popis: | Introduction: The role of E-cadherin and CD44 has been proven in the development and progression of cancerous and precancerous lesions. It seems that these two markers have a high ability to evaluate the premalignancy of lichen planus lesions and oral leukoplakia. This study aimed to investigate and compare the expression of CD44 and E-cadherin markers in oral leukoplakia, lichen planus, and oral squamous cell carcinoma (SCC). Material & Methods: This analytical-descriptive study was conducted on 60 blocks of lichen planus, leukoplakia, and squamous cell carcinoma. The blocks were stained by CD44 and E-cadherin antibodies. The obtained data were analyzed in SPSS software (version 22), and a P-value of 0.05 was considered statistically significant. Findings: Only 30% of the SCC samples expressed the CD44 marker, while 40% and 50% of leukoplakia and lichen planus samples expressed the CD44 marker, respectively. The expression of the E-cadherin marker in SCC samples was 40% in the range of staining, while it was 50% and 60% in leukoplakia and lichen planus, respectively. There was not a significant difference between the staining intensity of CD44 and E-cadherin (P |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|