Plasma metabolomic profile is near-normal in people with HIV on long-term suppressive antiretroviral therapy

Autor: Ana Virseda-Berdices, Rubén Martín-Escolano, Juan Berenguer, Juan González-García, Oscar Brochado-Kith, David Rojo, Amanda Fernández-Rodríguez, Leire Pérez-Latorre, Victor Hontañón, Coral Barbas, Salvador Resino, María Ángeles Jiménez-Sousa
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Druh dokumentu: article
ISSN: 2235-2988
DOI: 10.3389/fcimb.2024.1340610
Popis: BackgroundCombination antiretroviral therapy (ART) has transformed human immunodeficiency virus (HIV) infection in people with HIV (PWH). However, a chronic state of immune activation and inflammation is maintained despite achieving HIV suppression and satisfactory immunological recovery. We aimed to determine whether the plasma metabolomic profile of PWH on long-term suppressive ART and immunologically recovered approximates the normality by comparison with healthy controls with similar age and gender.MethodsWe carried out a cross-sectional study in 17 PWH on long-term ART (HIV-RNA
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