Deconvoluting cellular neighborhoods in pancreatic ductal adenocarcinoma

Autor:	Jessica Castrillon Lal
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Biology (General) QH301-705.5
Zdroj:	Communications Biology, Vol 5, Iss 1, Pp 1-2 (2022)
Druh dokumentu:	article
ISSN:	2399-3642
DOI:	10.1038/s42003-022-04032-1
Popis:	Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers, with less than 10% of patients surviving more than five years. A major challenge of PDAC is understanding the complexity of the tumor architecture and identifying targetable cellular phenotypes that can inform clinical decision-making. Hwang et al. recently harnessed spatially-resolved transcriptomics to characterize gene expression profiles across PDAC tumor slices and identified recurrent expression patterns in malignant and fibroblast cellular neighborhoods that correlated with treatment outcomes.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/98048d1a3d9645e5b2a45179ee13b97c Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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