An updated overview on the regulatory circuits of polyhydroxyalkanoates synthesis

Autor: Ruchira Mitra, Tong Xu, Guo‐Qiang Chen, Hua Xiang, Jing Han
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Microbial Biotechnology, Vol 15, Iss 5, Pp 1446-1470 (2022)
Druh dokumentu: article
ISSN: 1751-7915
DOI: 10.1111/1751-7915.13915
Popis: Summary Polyhydroxyalkanoates (PHA) are a promising and sustainable alternative to the petroleum‐based synthetic plastics. Regulation of PHA synthesis is receiving considerable importance as engineering the regulatory factors might help developing strains with improved PHA‐producing abilities. PHA synthesis is dedicatedly regulated by a number of regulatory networks. They tightly control the PHA content, granule size and their distribution in cells. Most PHA‐accumulating microorganisms have multiple regulatory networks that impart a combined effect on PHA metabolism. Among them, several factors ranging from global to specific regulators, have been identified and characterized till now. This review is an attempt to categorically summarize the diverse regulatory circuits that operate in some important PHA‐producing microorganisms. However, in several organisms, the detailed mechanisms involved in the regulation of PHA synthesis is not well‐explored and hence further research is needed. The information presented in this review might help researcher to identify the prevailing research gaps in PHA regulation.
Databáze: Directory of Open Access Journals
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