Relative contributions of family history and a polygenic risk score on COPD and related outcomes: COPDGene and ECLIPSE studies
| Autor: | Matthew Moll, Sharon M. Lutz, Auyon J. Ghosh, Phuwanat Sakornsakolpat, Craig P. Hersh, Terri H. Beaty, Frank Dudbridge, Martin D. Tobin, Murray A. Mittleman, Edwin K. Silverman, Brian D. Hobbs, Michael H. Cho |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | BMJ Open Respiratory Research, Vol 7, Iss 1 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2052-4439 12057541 |
| DOI: | 10.1136/bmjresp-2020-000755 |
| Popis: | Introduction Family history is a risk factor for chronic obstructive pulmonary disease (COPD). We previously developed a COPD risk score from genome-wide genetic markers (Polygenic Risk Score, PRS). Whether the PRS and family history provide complementary or redundant information for predicting COPD and related outcomes is unknown.Methods We assessed the predictive capacity of family history and PRS on COPD and COPD-related outcomes in non-Hispanic white (NHW) and African American (AA) subjects from COPDGene and ECLIPSE studies. We also performed interaction and mediation analyses.Results In COPDGene, family history and PRS were significantly associated with COPD in a single model (PFamHx |
| Databáze: | Directory of Open Access Journals |
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