Autor: |
Yongchao Wu, Xiaoqi Sun, Haoying Li, Xi Chu, Yucong Xue, Jiaying Qi, Qingzhong Jia, Xue Han, Li Chu, Shengjiang Guan, Xiangting Wang |
Jazyk: |
angličtina |
Rok vydání: |
2023 |
Předmět: |
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Zdroj: |
Journal of Functional Foods, Vol 105, Iss , Pp 105551- (2023) |
Druh dokumentu: |
article |
ISSN: |
1756-4646 |
DOI: |
10.1016/j.jff.2023.105551 |
Popis: |
6-Gingerol (6G) is the main phenolic active component of ginger, which has a certain protective effect against liver injury induced by drugs, and chemical pollutants. However, the mechanism of protection of 6G against arsenic trioxide (ATO)-induced liver injury remains unclear. The network pharmacology and animal experiment results respectively indicated that oxidative stress and inflammatory responses were closely related to ATO-induced liver injury. 6G can alleviate ATO-induced liver injury and oxidative stress. Furthermore, 6G can attenuate the release of pro-inflammatory factors induced by ATO and reduce the expressions of NLRP3, ASC, Caspase-1 and gasdermin-D. The results showed that the activation of NLRP3 inflammatory and its induced pyroptosis play critical roles in liver injury caused by ATO. Furthermore, 6G can suppress the ROS-NLRP3 inflammasome signaling pathway, which may be an effective strategy for the treatment of ATO-induced liver injury. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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