Effectiveness of Sambucus ebulus Leaf Extract in Treatment of Cutaneous Leishmaniasis: A Double Blind Clinical Trial
| Autor: | Omid Mozafari, Naser Behnampour, Bagher Pahlevanzadeh, Safoora Saberi, Ilay Mozafari, Jafar Akbari, Mohammad Ali Ebrahimzadeh |
|---|---|
| Jazyk: | English<br />Persian |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Journal of Mazandaran University of Medical Sciences, Vol 29, Iss 181, Pp 120-124 (2020) |
| Druh dokumentu: | article |
| ISSN: | 1735-9260 1735-9279 |
| Popis: | Background and purpose: Cutaneous leishmaniasis is a skin disease manifested as chronic ulcerative skin lesions. Current standard therapies for this disease are associated with some problems such as high cost, numerous side effects, need for injections, and drug resistance. Sambucus ebulus is used in treatment of skin inflammation. This study aimed at investigating the effects of S. ebulus leaf extract on cutaneous leishmanisis. Materials and methods: This clinical trial was performed in 110 patients who were divided into intervention (n=55) and control groups (n=55). All patients received the standard treatment for leishmanisis. In addition, the intervention group received topical treatment of S. ebulus leaf extract 5%, while the control group received placebo. The therapy was continued until complete epithelialization of the lesions. Before the intervention and at the end of each week (until complete epithelialization of the lesions), healing progress and clinical characteristics of the lesions, including the size, induration, and degree of epithelialization were recorded. Results: The intervention accelerated the decrease in mean diameter of lesions (P |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|