Acute bacterial meningitis without cerebrospinal fluid pleocytosis in children: results from a nationwide prospective surveillance system between 2001 and 2022

Autor: Lama Jaber, Corinne Levy, Naïm Ouldali, Emmanuelle Varon, Muhamed-Kheir Taha, Stéphane Bonacorsi, Stéphane Béchet, François Angoulvant, Robert Cohen, Alexis Rybak
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: International Journal of Infectious Diseases, Vol 149, Iss , Pp 107256- (2024)
Druh dokumentu: article
ISSN: 1201-9712
DOI: 10.1016/j.ijid.2024.107256
Popis: Objectives: We aimed to describe cases of acute bacterial meningitis (ABM) without cerebrospinal fluid (CSF) pleocytosis and the clinical and biological characteristics of affected children. Methods: We analyzed results of a nation-wide population-based prospective surveillance study of acute ABM in children aged 3 months to 15 years in France. Absence of CSF pleocytosis was defined as CSF leukocyte count ≤5/mm3. Results: We included 4754 cases of acute ABM from 2001 to 2022: 173 patients (3.6%) did not have CSF pleocytosis. ABM cases without CSF pleocytosis were mainly related to meningococcus (70% vs 44% with CSF pleocytosis, P
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