Autor: |
Patrick D. Bosshart, David Kalbermatter, Sara Bonetti, Dimitrios Fotiadis |
Jazyk: |
angličtina |
Rok vydání: |
2021 |
Předmět: |
|
Zdroj: |
Communications Chemistry, Vol 4, Iss 1, Pp 1-9 (2021) |
Druh dokumentu: |
article |
ISSN: |
2399-3669 |
DOI: |
10.1038/s42004-021-00564-5 |
Popis: |
The L-lactate-specific transporter SfMCT is a model SLC16 family homologue for the determination of inhibitors and potential drugs. Here, starting from a weakly-binding non-transported ligand, nanomolar affinity inhibitors of SfMCT are developed and crystal structures of the transporter-ligand complexes are presented unveiling interactions at the atomic level. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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