| Autor: |
Patrick D. Bosshart, David Kalbermatter, Sara Bonetti, Dimitrios Fotiadis |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Communications Chemistry, Vol 4, Iss 1, Pp 1-9 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2399-3669 |
| DOI: |
10.1038/s42004-021-00564-5 |
| Popis: |
The L-lactate-specific transporter SfMCT is a model SLC16 family homologue for the determination of inhibitors and potential drugs. Here, starting from a weakly-binding non-transported ligand, nanomolar affinity inhibitors of SfMCT are developed and crystal structures of the transporter-ligand complexes are presented unveiling interactions at the atomic level. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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