| Autor: |
Alexander Golubev, Luc Negroni, Filipp Krasnovid, Shamil Validov, Gulnara Yusupova, Marat Yusupov, Konstantin Usachev |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
FEBS Open Bio, Vol 10, Iss 7, Pp 1342-1347 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2211-5463 |
| DOI: |
10.1002/2211-5463.12901 |
| Popis: |
Antibiotic‐resistant Staphylococcus aureus is becoming a major burden on health care systems in many countries, necessitating the identification of new targets for antibiotic development. Elongation Factor P (EF‐P) is a highly conserved elongation protein factor that plays an important role in protein synthesis and bacteria virulence. EF‐P undergoes unique posttranslational modifications in a stepwise manner to function correctly, but experimental information on EF‐P posttranslational modifications is currently lacking for S. aureus. Here, we expressed EF‐P in S. aureus to analyze its posttranslational modifications by mass spectrometry and report experimental proof of 5‐aminopentanol modification of S. aureus EF‐P. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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