Parasagittal dural space and cerebrospinal fluid (CSF) flow across the lifespan in healthy adults

Autor: Kilian Hett, Colin D. McKnight, Jarrod J. Eisma, Jason Elenberger, Jennifer S. Lindsey, Ciaran M. Considine, Daniel O. Claassen, Manus J. Donahue
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-13 (2022)
Druh dokumentu: article
ISSN: 2045-8118
DOI: 10.1186/s12987-022-00320-4
Popis: Abstract Background Recent studies have suggested alternative cerebrospinal fluid (CSF) clearance pathways for brain parenchymal metabolic waste products. One fundamental but relatively under-explored component of these pathways is the anatomic region surrounding the superior sagittal sinus, which has been shown to have relevance to trans-arachnoid molecular passage. This so-called parasagittal dural (PSD) space may play a physiologically significant role as a distal intracranial component of the human glymphatic circuit, yet fundamental gaps persist in our knowledge of how this space changes with normal aging and intracranial bulk fluid transport. Methods We re-parameterized MRI methods to assess CSF circulation in humans using high resolution imaging of the PSD space and phase contrast measures of flow through the cerebral aqueduct to test the hypotheses that volumetric measures of PSD space (1) are directly related to CSF flow (mL/s) through the cerebral aqueduct, and (2) increase with age. Multi-modal 3-Tesla MRI was applied in healthy participants (n = 62; age range = 20–83 years) across the adult lifespan whereby phase contrast assessments of CSF flow through the aqueduct were paired with non-contrasted T 1-weighted and T 2-weighted MRI for PSD volumetry. PSD volume was extracted using a recently validated neural networks algorithm. Non-parametric regression models were applied to evaluate how PSD volume related to tissue volume and age cross-sectionally, and separately how PSD volume related to CSF flow (significance criteria: two-sided p
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