Age- and sex-related regional compressive strength characteristics of human lumbar vertebrae in osteoporosis

Autor: Márta Kurutz, Judit Donáth, Miklós Gálos, Péter Varga, Béla Fornet
Jazyk: angličtina
Rok vydání: 2008
Předmět:
Zdroj: Journal of Multidisciplinary Healthcare, Vol 2008, Iss default, Pp 105-121 (2008)
Druh dokumentu: article
ISSN: 1178-2390
Popis: Márta Kurutz1, Judit Donáth3, Miklós Gálos2, Péter Varga1, Béla Fornet41Department of Structural Mechanics; 2Department of Construction Materials, Budapest University of Technology and Economics, Budapest, Hungary; 3Department of Reumatology, National Institute for Reumatology, Budapest, Hungary; 4Department of Radiology, County Hospital András Jósa, Nyiregyháza, HungaryObjective: To obtain the compressive load bearing and energy absorption capacity of lumbar vertebrae of osteoporotic elderly for the everyday medical praxis in terms of the simple diagnostic data, like computed tomography (CT), densitometry, age, and sex.Methods: Compressive test of 54 osteoporotic cadaver vertebrae L1 and L2, 16 males and 38 females (age range 43–93, mean age 71.6 ± 13.3 years, mean bone mineral density (BMD) 0.377 ± 0.089 g/cm2, mean T-score −5.57 ± 0.79, Z-score −4.05 ± 0.77) was investigated. Based on the load-displacement diagrams and the measured geometrical parameters of vertebral bodies, proportional, ultimate and yield stresses and strains, Young’s modulus, ductility and energy absorption capacity were determined. Three vertebral regions were distinguished: superior, central and inferior regions, but certain parameters were calculated for the upper/lower intermediate layers, as well. Cross-sectional areas, and certain bone tissue parameters were determined by image analysis of CT pictures of vertebrae. Sex- and age-related decline functions and trends of strength characteristics were determined.Results: Size-corrected failure load was 15%–25% smaller in women, proportional and ultimate stresses were about 30%–35% smaller for women in any region, and 20%–25% higher in central regions for both sexes. Young’s moduli were about 30% smaller in women in any region, and 20%–25% smaller in the central region for both sexes. Small strains were higher in males, large strains were higher in females, namely, proportional strains were about 25% larger in men, yield and ultimate strains were quasi equal for sexes, break strains were 10% higher in women. Ultimate energy absorption capacity was 10%–20% higher in men; the final ductile energy absorption capacity was quasi equal for sexes in all levels. Age-dependence was stronger for men, mainly in central regions (ultimate load, male: r = −0.66, p
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