Effect of Korean Herbal Formula (Modified Ojayeonjonghwan) on Androgen Receptor Expression in an Aging Rat Model of Late Onset Hypogonadism

Autor: Sae Woong Choi, Seung Hwan Jeon, Eun Bi Kwon, Guan Qun Zhu, Kyu Won Lee, Jin Bong Choi, Hyun Cheol Jeong, Kang Sup Kim, Sang Rak Bae, Woong Jin Bae, Su Jin Kim, Hyuk Jin Cho, U-Syn Ha, Sung-Hoo Hong, Sung Yeoun Hwang, Sae Woong Kim
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: The World Journal of Men's Health, Vol 37, Iss 1, Pp 105-112 (2019)
Druh dokumentu: article
ISSN: 2287-4208
2287-4690
DOI: 10.5534/wjmh.180051
Popis: Purpose: Testosterone replacement therapy is an effective treatment for late-onset hypogonadism (LOH) despite a few con-traindications and side-effects. The aim of this study was to determine whether modified Ojayeonjonghwan (KH-204, Korean herbal formula) improved LOH. KH-204 is a strong antioxidant herbal formula. We evaluated the effect of Korean herbal pre-scription on androgen receptor (AR) expression in an aged rat model of LOH. Materials and Methods: Eighteen-month-old rats were used as aged LOH rat models. Eighteen Sprague-Dawley rats were ran-domly divided into three equal groups of six animals each and treated with one of the following: 1) normal control group (oral administration with distilled water, n=6), 2) KH-204 200 group (oral administration with 200 mg/kg of KH-204, n=6), and 3) KH-204 400 group (oral administration with 400 mg/kg of KH-204, n=6). After four weeks of treatment (once daily, distilled water or KH-204), serum testosterone levels, changes in testicular and epididymal weight, Western blotting analysis of AR ex-pression and measurement of oxidative stress were examined. Results: Treatment with the herbal formulation KH-204 200 mg/kg and 400 mg/kg (1) increased the weights of testis and epi-didymis; (2) increased the level of serum testosterone; (3) increased the level of superoxide dismutase and reduced the level of 8-hydroxy-20-deoxyguanosine; and (4) upregulated AR expression in testicular tissue. Conclusions: KH-204 might be an effective alternative for LOH. It improves antioxidant mechanisms and increases testicular AR expression without side-effects.
Databáze: Directory of Open Access Journals
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