Targeting autophagy: A promising approach for the treatment of breast cancer brain metastases

Autor:	Steffan T. Nawrocki, Claudia M. Espitia, Maria Janina Carrera Espinoza, Madison E. Gamble, Sruthi Sureshkumar, Mengyang Chang, Wei Wang, Jennifer S. Carew
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	autophagy brain metastasis breast cancer hydroxychloroquine lapatinib Therapeutics. Pharmacology RM1-950
Zdroj:	Clinical and Translational Discovery, Vol 4, Iss 4, Pp n/a-n/a (2024)
Druh dokumentu:	article
ISSN:	2768-0622
DOI:	10.1002/ctd2.340
Popis:	Abstract Patients with breast tumours that metastasise to the brain have limited treatment options and a very poor prognosis. More effective therapeutic strategies are desperately needed for this patient population. Recent evidence demonstrates that brain metastases arising from breast tumours display altered energy production that results in enhanced autophagy. Preclinical studies have shown that genetically or pharmacologically disrupting the autophagy pathway significantly decreases the brain metastatic burden, resulting in improved animal survival and increased sensitivity to lapatinib. These findings pave the way for the development of novel strategies targeting autophagy for breast cancer patients with brain metastatic disease.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/97c369482c3f46e5a1d2b1d78a7128ee Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.