| Autor: |
Matthew S. Zabriskie, Chuanzhuo Wang, Shuping Wang, Matthew D. Alexander |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Animal Models and Experimental Medicine, Vol 3, Iss 2, Pp 208-213 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2576-2095 |
| DOI: |
10.1002/ame2.12125 |
| Popis: |
Abstract Intracranial atherosclerotic disease (ICAD) is the most common cause of ischemic stroke. Poor understanding of the disease due to limited human data leads to imprecise treatment. Apolipoprotein E knockout (ApoE‐KO) rabbits were compared to an existing model, the Watanabe heritable hyperlipidemic (WHHL) rabbit, and wild‐type New Zealand white (NZW) rabbit controls. Intracranial artery samples were assessed on histopathology for the presence of ICAD. Logistic and ordinal regression analyses were performed to assess for disease presence and severity, respectively. Eighteen rabbits and 54 artery segments were analyzed. Univariate logistic analysis confirmed the presence of ICAD in model rabbits (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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