Urinary hsv2-miR-H9 to hsa-miR-3659 ratio is an effective marker for discriminating prostate cancer from benign prostate hyperplasia in patients within the prostate-specific antigen grey zone
| Autor: | Ho Won Kang, Young Joon Byun, Sung Min Moon, Kyeong Kim, Xuan-Mei Piao, Chuang-Ming Zheng, Sung-Kwon Moon, Yung Hyun Choi, Won Tae Kim, Yong-June Kim, Sang-Cheol Lee, Seok Joong Yun, Wun-Jae Kim |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Investigative and Clinical Urology, Vol 63, Iss 2, Pp 238-244 (2022) |
| Druh dokumentu: | article |
| ISSN: | 20210493 2466-0493 2466-054X |
| DOI: | 10.4111/icu.20210493 |
| Popis: | Purpose: Tumor microRNAs (miRNAs) are released to biofluids directly or indirectly. Although urinary miRNAs are promising non-invasive biomarkers for the diagnosis of prostate cancer (PCa), their clinical application is challenging for technical reasons. We examined the efficacy of urinary hsv2-miR-H9 to hsa-miR-3659 ratio as a non-invasive diagnostic biomarker of PCa. Materials and Methods: The expression of urinary miRNAs was quantified by real-time PCR in 116 samples from 53 patients with benign prostatic hyperplasia (BPH) and 63 patients with PCa. The miRNA expression ratio was calculated using an upregulated miRNA (hsv2-miR-H9) as the numerator and a downregulated miRNA (hsa-miR-3659) as the denominator. Results: The urinary miR-H9 to miR-3659 ratio was significantly higher in PCa than in BPH controls (p |
| Databáze: | Directory of Open Access Journals |
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