Why Is Aneuploidy Associated with Favorable Outcome in Neuroblastoma?

Autor:	Gian Paolo Tonini
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	neuroblastoma tumorigenesis chromosome instability aneuploidy Microbiology QR1-502
Zdroj:	Biomolecules, Vol 11, Iss 8, p 1116 (2021)
Druh dokumentu:	article
ISSN:	2218-273X
DOI:	10.3390/biom11081116
Popis:	Neuroblastoma is a pediatric cancer, onset with localized as well as metastatic disease. Localized tumors usually show a high content of aneuploid cells. It is suggested that aneuploid cells with numerical copy number variation (CNV) are generated by chromosome instability (CIN). Patients with a localized tumor respond well to the therapy and show a good outcome. On the contrary, patients with a metastatic tumor have worse outcomes and the cells with structural CNV show high levels of CIN. It is proposed that a favorable outcome in patients with localized disease is associated to the grade of CIN.
Databáze:	Directory of Open Access Journals
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