| Autor: |
Bente M. Houtman, Iris Walraven, Elke de Grouw, Richard W. M. van der Maazen, Leontien C. M. Kremer, Eline van Dulmen-den Broeder, Marry M. van den Heuvel-Eibrink, Wim J. E. Tissing, Dorine Bresters, Helena J. H. van der Pal, Andrica C. H. de Vries, Marloes Louwerens, Margriet van der Heiden-van der Loo, Sebastian J. C. Neggers, Geert O. Janssens, Nicole M. A. Blijlevens, Annechien J. A. Lambeck, Frank Preijers, Jacqueline J. Loonen |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Journal of Immunology Research, Vol 2023 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2314-7156 |
| DOI: |
10.1155/2023/5863995 |
| Popis: |
Background. Childhood cancer survivors (CCS) who received radiotherapy involving the spleen or total body irradiation (TBI) might be at risk for splenic dysfunction. A comprehensive screening test for examining splenic dysfunction is lacking. Objective. We investigated whether IgM memory B-cells could be used to assess splenic dysfunction in CCS who received a splenectomy, radiotherapy involving the spleen, or TBI. Methods. All CCS were enrolled from the DCCSS-LATER cohort. We analyzed differences in IgM memory B-cells and Howell–Jolly bodies (HJB) in CCS who had a splenectomy (n = 9), received radiotherapy involving the spleen (n = 36), or TBI (n = 15). IgM memory B-cells |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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