Contrast-enhanced ultrasound Liver Imaging Reporting and Data System (LI-RADS) in hepatocellular carcinoma ≤ 5cm: biological characteristics and patient outcomes

Autor: Wen-jia Cai, Minghua Ying, Rong-qin Zheng, Jintang Liao, Baoming Luo, Lina Tang, Wen Cheng, Hong Yang, An Wei, Yilin Yang, Hui Wang, Yan-chun Luo, Cun Liu, Hui Zhong, Qi Yang, Jie Yu, Ping Liang
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Liver Cancer, p 1 (2023)
Druh dokumentu: article
ISSN: 2235-1795
1664-5553
DOI: 10.1159/000527498
Popis: Introduction: The present study aimed to evaluate the influence of biological characteristics of hepatocellular carcinoma (HCC) on the Liver Imaging Reporting and Data System (LI-RADS) v2017 category of contrast-enhanced ultrasound (CEUS) in patients with high risk and compare the outcomes among different categories after radical resection. Methods: Between June 2017 and December 2020, standardized CEUS data of liver nodules were prospectively collected from multiple centers across China. We conducted a retrospective analysis of the prospectively collected data on HCCs measuring no more than 5 cm as diagnosed by pathology. LI-RADS categories were assigned after thorough evaluation of CEUS features. Then, CEUS LI-RADS categories and major features were compared in different differentiation, Ki-67 and microvascular invasion (MVI) statuses. Differences in recurrence-free survival (RFS) among different LI- RADS categories were further analyzed. Results: A total of 293 HCC nodules in 293 patients were included. This study revealed significant differences in the CEUS LI-RADS category of HCCs among differentiation (p 0.05). With a median follow-up of 23 months, HCCs assigned to different CEUS LI-RADS classes showed no significant differences in RFS after resection. Conclusions: Biological characteristics of HCC, including differentiation and level of Ki-67 expression could influence major features of CEUS and impact the CEUS LI-RADS category. HCCs in different CEUS LI-RADS categories showed no significant differences in RFS after resection.
Databáze: Directory of Open Access Journals
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