Human amniotic epithelial cells exert anti-cancer effects through secretion of immunomodulatory small extracellular vesicles (sEV)

Autor:	Mohammad-Reza Bolouri, Roya Ghods, Kayhan Zarnani, Sedigheh Vafaei, Reza Falak, Amir-Hassan Zarnani
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Stem cells Human amniotic epithelial cell Cancer Small extracellular vesicles (sEV) Cytotoxic T lymphocyte Warburg’s effect Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
Zdroj:	Cancer Cell International, Vol 22, Iss 1, Pp 1-18 (2022)
Druh dokumentu:	article
ISSN:	1475-2867
DOI:	10.1186/s12935-022-02755-z
Popis:	Highlights Anti-cancer effects of hAEC depend on cancer type. Cross-reactive humoral responses do not mediate anti-cancer effects of hAEC. Anti-cancer effects of hAECs are mainly mediated by small-extracellular vesicles (sEV). hAEC-derived sEV (AD-sEV) trigger the Warburg’s effect leading to Arginine consumption and cancer cell apoptosis. AD-sEV substantially inhibits tumor development and increases survival and CTL responses.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/97a6717821df433da8b431c3c3a1bc5a Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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