Characterization of bone metabolism in hungarian psoriatic arthritis patients: a case–control study

Autor: Zsófia Pethő, Edit Kalina, Zoltán Pap, Katalin Hodosi, Rebeka Falcsik, Ádám Balogh, Zoltán Szekanecz, Harjit Pal Bhattoa
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: BMC Musculoskeletal Disorders, Vol 22, Iss 1, Pp 1-9 (2021)
Druh dokumentu: article
ISSN: 1471-2474
DOI: 10.1186/s12891-021-03952-z
Popis: Abstract Background Skeletal manifestations are predominant in psoriatic arthritis (PsA). The aim of this cross-sectional, case-control study is the complex assessment of areal and volumetric bone mineral density (BMD), fracture risk, vitamin D status and bone turnover markers, and its association with disease-related variables. Methods Lumbar spine (L1-L4) and femoral neck (FN) areal, and distal radius (DR) volumetric BMD, 10-year probability of major and hip osteoporotic fracture as assessed by the fracture risk assessment (FRAX) tool, markers of bone metabolism and disease activity were assessed. Results Upon comparison of the disease and age- and sex-matched control groups, there was a statistically significant difference in FN areal (0.952 (0.607–1.292) g/cm2 vs. 1.016 (0.760–1.550) g/cm2; p = 0.001) and DR total volumetric (284.3 (138.9–470.3) mg/cm3 vs. 367.0 (287.0–412.0) mg/cm3; p
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