| Autor: |
Elizabeth B. Umoren, Idara A. Okon, Emmanuel U. Modo, Okon E. Etim, Providence I. Brown, Daniel U. Owu, Augustine I.L. Bassey |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Phytomedicine Plus, Vol 3, Iss 2, Pp 100450- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2667-0313 |
| DOI: |
10.1016/j.phyplu.2023.100450 |
| Popis: |
Background: A great number of modern medicines derived from plants are considered as important sources of medicinal agents to treat different diseases. J. tanjorensis belongs to the family Euphorbiaceae, which is known for various medicinal uses. Purpose: The hepatoprotective effect of ethanolic extract of J. tanjorensis Euphorbiaceae and maintenance of electrolytes balance in aspirin-induced hepatotoxic condition in Wistar rats was studied. Methods: 20 Wistar rats of both sexes weighing between (180–200 g) were divided into 4 groups of 5 rats each. normal rat (group 1); J. tanjorensis Euphorbiaceae (200 mg/kg group 2); aspirin (250 mg/kg group 3); aspirin (250 mg/kg) + J. tanjorensis Euphorbiaceae (200 mg/kg group 4). Serum levels of the enzymes aspartate transaminase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and electrolytes (Na+, K+, Cl−, and HCO3−) was assessed at the end of treatment which lasted twelve (12) weeks. Results: When compared to control, J. tanjorensis Euphorbiaceae - treated, and aspirin+ J. tanjorensis Euphorbiaceae - treated groups, blood electrolyte results in aspirin-treated group indicated a significant decrease (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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