Effect of ATP and Bax on the apoptosis of Eimeria tenella host cells

Autor: Zhiyong Xu, Mingxue Zheng, Li Zhang, Xuesong Zhang, Yan Zhang, Xiaozhen Cui, Xin Gong, Rou Xi, Rui Bai
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: BMC Veterinary Research, Vol 13, Iss 1, Pp 1-9 (2017)
Druh dokumentu: article
ISSN: 1746-6148
DOI: 10.1186/s12917-017-1313-z
Popis: Abstract Background Eimeria tenella (E. tenella) is a species of Eimeria that causes haemorrhagic caecal coccidiosis, resulting in major economic losses in the global poultry industry. After E. tenella infection, the amount of ATP and Bax in host cells showed highly significant changes. Therefore, it is necessary to investigate the effects of ATP and Bax on the apoptosis of E. tenella host cells. Results The ATP-treated group and the V5-treated group had higher E. tenella infection rates than the untreated group at 24, 48, 72, 96, and 120 h after infection with E. tenella. The results of flow cytometry showed that compared with the control group, the mitochondrial permeability transition pore (MPTP) opening in the untreated group was highly significantly increased (P
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