| Autor: |
Cong Shen, BS, Lan-Lan Zhong, MS, Yongqiang Yang, PhD, Yohei Doi, ProfMD, David L Paterson, ProfMD, Nicole Stoesser, MD, Furong Ma, BS, Mohamed Abd El-Gawad El-Sayed Ahmed, PhD, Siyuan Feng, PhD, Songyin Huang, ProfMD, Hong-Yu Li, ProfMD, Xi Huang, ProfPhD, Xin Wen, BS, Zihan Zhao, MS, Minmin Lin, BS, Guanping Chen, BS, Wanfei Liang, BS, MS, Yingjian Liang, Yong Xia, ProfMD, Min Dai, ProfMD, Ding-Qiang Chen, ProfMD, Liyan Zhang, ProfMD, Kang Liao, ProfMD, Guo-Bao Tian, ProfPhD |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
The Lancet Microbe, Vol 1, Iss 1, Pp e34-e43 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2666-5247 |
| DOI: |
10.1016/S2666-5247(20)30005-7 |
| Popis: |
Summary: Background: The global dissemination of colistin resistance encoded by mcr-1 has been attributed to extensive use of colistin in livestock, threatening colistin efficacy in medicine. The emergence of mcr-1 in common pathogens, such as Escherichia coli, is of particular concern. China banned the use of colistin in animal feed from May 1, 2017. We investigated subsequent changes in mcr-1 prevalence in animals, humans, food, and the environment, and the genomic epidemiology of mcr-1-positive E coli (MCRPEC). Methods: Sampling was done before (October to December, 2016) and after (October to December, 2017, and 2018, respectively) the colistin ban. 3675 non-duplicate pig faecal samples were collected from 14 provinces (66 farms) in China to measure intervention-related changes in mcr-1 prevalence. 15 193 samples were collected from pigs, healthy human volunteers, patients colonised or infected with Enterobacteriaceae who were admitted to hospital, food and the environment in Guangzhou, to characterise source-specific mcr-1 prevalence and the wider ecological effect of the ban. From these samples, 688 MCRPEC were analysed with whole genome sequencing, plasmid conjugation, and S1 pulsed-field gel electrophoresis with Southern blots to characterise associated genomic changes. Findings: After the ban, mcr-1 prevalence decreased significantly in national pig farms, from 308 (45%) of 684 samples in 2016 to 274 (19%) of 1416 samples in 2018 (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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