Targeting Approaches of Nanomedicines in Acute Myeloid Leukemia

Autor: Xiao Huang, Hai Lin, Feng Huang, Yuning Xie, Ka Hong Wong, Xiaoyu Chen, Dongyue Wu, Aiping Lu, Zhijun Yang
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Dose-Response, Vol 17 (2019)
Druh dokumentu: article
ISSN: 1559-3258
15593258
DOI: 10.1177/1559325819887048
Popis: Acute myeloid leukemia (AML) is a hematological malignancy, which is commonly associated with high incidence and mortality among adult patients. The standard induction regimen for AML has been substantially unchanged over the past 40 years, for which novel nanomedicines have represented a promising strategy in AML therapies. Despite developments of multiple nanoparticles formulated with drugs or genes, less there is not much information available about approaches in AML is available. This review presents an overview of nanomedicines currently being evaluated in AML. First, it briefly summarized conventional chemotherapies in use. Second, nanomedicines presently ongoing in clinical trials or preclinical researches were classified and described, with illustrative examples from recent literatures. Finally, limitations and potential safety issues concerns in clinical translation of AML treatment were discussed as well.
Databáze: Directory of Open Access Journals
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