The Effects of Combined Social Cognition and Interaction Training and Paliperidone on Early-Onset Schizophrenia

Autor: Yichen Li, Ke Sun, Denghua Liu, Mo-Xian Chen, Guo Li, Jun Ma, Xiaofan Zhang
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Frontiers in Psychiatry, Vol 11 (2020)
Druh dokumentu: article
ISSN: 1664-0640
DOI: 10.3389/fpsyt.2020.525492
Popis: BackgroundThe limitations associated with antipsychotics in early-onset schizophrenia patients have stimulated more interest in psychological interventions in this population. Nevertheless, the isolated psychosocial interventions are unrealistic in a treatment success covering the complex array of symptoms, and the psychosocial interventions could be an adjunct treatment to the pharmacological treatment. It is necessary to find the benefits of psychological interventions with limited and targeted use of antipsychotics. Social cognition and interaction training (SCIT) was a program for social cognitive rehabilitation in adult schizophrenia. However, it is unclear how generalizable this is to early-onset patients.MethodsThe current study tested this hypothesis that combined SCIT and paliperidone was superior to paliperidone alone in treating early-onset schizophrenia patients on cognitive, functional, and symptom outcomes. Two hundred eight inpatients with schizophrenia aged 13 to 17 years old participated in a 24-week work intervention program. Patients completed a battery of measures administered at a pre-SCIT intervention baseline, 4, 8, 12, and 24 weeks post-SCIT, respectively.ResultsSCIT had significant added benefits above paliperidone for the speed of processing, attention/vigilance, and social cognition of the Chinese version of MATRICS consensus cognitive battery (MCCB) domains (p
Databáze: Directory of Open Access Journals