| Autor: |
Vera M. Todd, Lawrence A. Vecchi, Miranda E. Clements, Katherine P. Snow, Cayla D. Ontko, Lauren Himmel, Christopher Pinelli, Marjan Rafat, Rachelle W. Johnson |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Communications Biology, Vol 4, Iss 1, Pp 1-18 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2399-3642 |
| DOI: |
10.1038/s42003-021-02648-3 |
| Popis: |
Todd et al employ a PyMT-driven spontaneous murine mammary carcinoma model with mammary-specific deletion of hypoxia inducible factors Hif1α, Hif2α, or von Hippel-Lindau factor to further investigate their role in bone and lung metastasis. They find that HIF signaling in breast tumours controls tumour dissemination in a site-specific manner, which could inform the development of therapies targeting metastasis. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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