| Autor: |
OLDŘICH FARSA, MILAN DOČKAL, JANA KOVÁČIKOVÁ, MÁRIA BENEŠOVÁ |
| Jazyk: |
angličtina |
| Rok vydání: |
2008 |
| Předmět: |
|
| Zdroj: |
Journal of the Serbian Chemical Society, Vol 73, Iss 8-9, Pp 771-780 (2008) |
| Druh dokumentu: |
article |
| ISSN: |
0352-5139 |
| Popis: |
A series of 9 phenoxyacetic acids substituted in the o-, m-, and p-position of benzene ring with 2-(2-oxo-1-azacycloalkyl)acetamidic moiety containing 5–7-membered w-lactam ring was prepared by a 4-step synthetic pro¬cedure. Five selected substances of this series were tested in vitro for inhibition of porcine kidney aminopeptidase M. 2-{4-[2-(2-Oxoperhydroazepin-1-yl)acetamido]phenoxy}acetic acid exhibited the highest activity with Ki = 243.6 mM. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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