Beneficial Effect of the Nonpeptidyl Low Molecular Weight Radical Scavenger IAC on Cultured Human Islet Function
| Autor: | Rita Mancarella, Silvia Del Guerra, Matilde Masini, Marco Bugliani, Luca Valgimigli, Gian Franco Pedulli, Moreno Paolini, Donatella Canistro, Andrea Armando, Antonio Soleti, Franco Filipponi, Franco Mosca, Ugo Boggi, Stefano Del Prato, Piero Marchetti, Roberto Lupi |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: | |
| Zdroj: | Cell Transplantation, Vol 17 (2008) |
| Druh dokumentu: | article |
| ISSN: | 0963-6897 1555-3892 |
| DOI: | 10.3727/096368908787236639 |
| Popis: | We examined a possible protective effect of the nonpeptidyl low molecular weight radical scavenger IAC [bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl)decanedioate di-hydrochloride] on isolated human islet cells against isolation and culture oxidative stress. Islets isolated from pancreases of nondiabetic multiorgan donors by collagenase digestion were purified by density gradient centrifugation. After the isolation, islets were either exposed or not exposed for 7 days to 10 μmol/L IAC. We found that IAC markedly reduced oxidative stress and ameliorated islets function. These results suggest that the use of IAC could be an interesting pharmacological approach for the treatment of the islets before transplantation. |
| Databáze: | Directory of Open Access Journals |
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