Dose-dependent Anti-inflammatory Effect of Silymarin in Experimental Animal Model of Acute Inflammation
| Autor: | Kasim M. Juma'a, Saad A. Hussain, Intesar T. Numan, Assad H. Siqar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Iraqi Journal of Pharmaceutical Sciences, Vol 18, Iss Suppl. (2017) |
| Druh dokumentu: | article |
| ISSN: | 2521-3512 1683-3597 |
| DOI: | 10.31351/vol18issSuppl.pp14-18 |
| Popis: | Silymarin, a flavolignans from seeds of ‘milk thistle’ “Silybum marianum†has been widely used from ancient times because of its excellent hepatoprotective action. It has been used clinically to treat liver disorders including acute and chronic viral hepatitis, toxin/drug-induced hepatitis and cirrhosis and alcoholic liver disease. The efficacy and dose-response effect of silymarin (125, 250 and 500 mg/kg) were assessed using egg albumin-induced paw edema in rats as a model of acute inflammation. In this model, 56 rats were used and allocated into 7 subgroups each containing 8 rats. All treatments were given intraperitonealy 30 minutes before induction of inflammation by egg albumin and then the increase in paw edema was measured 1h, 2h and 3h after induction of inflammation by using the vernier caliper. The results indicated that silymarin, at doses range used, significantly lowered paw edema (P |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|