Gating of TonB-dependent transporters by substrate-specific forced remodelling

Autor: Samuel J. Hickman, Rachael E. M. Cooper, Luca Bellucci, Emanuele Paci, David J. Brockwell
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms14804
Popis: Bacterial outer membrane TonB-dependent transporters (TBDTs) mediate the influx of several nutrients. Here the authors use single-molecule force spectroscopy to show that the interaction between TonB andEscherichia coliTBDT BtuB is mechanically resistant to the pulling that gates the BtuB channel.
Databáze: Directory of Open Access Journals