Donor‐defined mesenchymal stem cell antimicrobial potency against nontuberculous mycobacterium

Autor:	Tracey L. Bonfield, Morgan T. Sutton, David R. Fletcher, Michael A. Folz, Vaishnavi Ragavapuram, Rodrigo A. Somoza, Arnold I. Caplan
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	human mesenchymal stem cell donor potency and efficacy lung disease nontuberculous mycobacteria Medicine (General) R5-920 Cytology QH573-671
Zdroj:	Stem Cells Translational Medicine, Vol 10, Iss 8, Pp 1202-1216 (2021)
Druh dokumentu:	article
ISSN:	2157-6580 2157-6564
DOI:	10.1002/sctm.20-0521
Popis:	Abstract Chronic nontuberculous mycobacterial infections with Mycobacterium avium and Mycobacterium intracellulare complicate bronchiectasis, chronic obstructive airway disease, and the health of aging individuals. These insidious intracellular pathogens cause considerable morbidity and eventual mortality in individuals colonized with these bacteria. Current treatment regimens with antibiotic macrolides are both toxic and often inefficient at providing infection resolution. In this article, we demonstrate that human marrow‐derived mesenchymal stem cells are antimicrobial and anti‐inflammatory in vitro and in the context of an in vivo sustained infection of either M. avium and/or M. intracellulare.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/972fcace7d3b45f7bcc6940fc38549bb Zobrazit plný text záznamu Plný text View record in DOAJ