Steroid insensitive fixed airflow obstruction is not related to airway inflammation in older non-smokers with asthma

Autor:	K. O. Tonga, G. G. King, C. S. Farah, C. Thamrin, F. S. Tang, J. Santos, P. Sharma, D. G. Chapman, B. G. Oliver
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Fixed airflow obstruction Asthma Reduced lung elastic recoil Airway inflammation Diseases of the respiratory system RC705-779
Zdroj:	Respiratory Research, Vol 19, Iss 1, Pp 1-4 (2018)
Druh dokumentu:	article
ISSN:	1465-993X
DOI:	10.1186/s12931-018-0880-2
Popis:	Abstract There is limited evidence linking airway inflammation and lung function impairment in older non-smoking asthmatics with fixed airflow obstruction (FAO), which can develop despite treatment with inhaled corticosteroids (ICS). We assessed lung function (spirometry, forced oscillation technique (FOT)), lung elastic recoil and airway inflammation using bronchoalveolar lavage (BAL) in non-smoking adult asthmatics with FAO, following 2 months treatment with high-dose ICS/long-acting beta-agonist. Subjects demonstrated moderate FAO, abnormal FOT indices and loss of lung elastic recoil. This cross-sectional study showed a lack of a relationship between BAL neutrophils, eosinophils, inflammatory cytokines and lung function impairment. Other inflammatory pathways or the effect of inflammation on lung function over time may explain FAO development.
Databáze:	Directory of Open Access Journals
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