| Autor: |
Indresh Yadav, William Rosencrans, Rajib Basak, Jeroen A. van Kan, Johan R. C. van der Maarel |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Physical Review Research, Vol 2, Iss 1, p 013294 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2643-1564 |
| DOI: |
10.1103/PhysRevResearch.2.013294 |
| Popis: |
The intramolecular dynamics of double-stranded DNA confined to a long, straight, and rectangular channel with a cross-sectional diameter of 125 nm (two times the persistence length) is measured with fluorescence microscopy. The derived intermediate dynamic structure factors show predominant odd modes associated with end-to-end fluctuation and typical stretched exponential relaxation behavior pertaining to Rouse dynamics. Major confinement-induced slowing down of intramolecular fluctuation is observed, which may have important implications in biology and biotechnology. As predicted for free-draining in a quasi-one-dimensional conformation, the Rouse times show a cube rather than the classical, blob model predicted square dependence on the molecular weight. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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