| Autor: |
Prashanth Giridhar, Supriya Mallick, K.P. Haresh, Subhash Gupta, P.K. Julka, G.K. Rath |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Journal of the Egyptian National Cancer Institute, Vol 28, Iss 2, Pp 111-116 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
1110-0362 |
| DOI: |
10.1016/j.jnci.2015.07.002 |
| Popis: |
Introduction: Fibrosarcoma is a rare brain tumour with 33 cases reported so far. However, there is no clear consensus about the nature of the disease and treatment as well as outcome. Methods: A MEDLINE search was carried out using MESH terms like intracranial fibrosarcoma, intraspinal fibrosarcoma, fibrosarcoma meninges and fibrosarcoma brain. A total of 22 case reports and series reporting a total of 33 cases were identified. We here also report a case treated in our institute with adjuvant radiation and concurrent and maintenance temozolomide. Results: The age of presentation ranged from 2 months to 75 years (Median = 17 years). The gender ratio was found to be M:F of 1.75–1. Treatment modalities were described for 17 cases. Surgery was part of treatment in all cases while radiation was a part of treatment in 59% of cases (n = 10) and chemotherapy in 29% cases (n = 5). Survival data were available only for 8 cases and ranged from 1 day to 8 years (Median = 15.5 months). Conclusion: Fibrosarcoma is a rare disease with dismal prognosis. Surgery remains the cornerstone of therapy. Radiation confers long term disease control and survival. Chemotherapy needs to be evaluated for these tumours to improve survival. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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