A retrospective analysis of ezrin protein and mRNA expression in breast cancer: Ezrin expression is associated with patient survival and survival of patients with receptor‐positive disease

Autor: Sarah J. Storr, Victoria Hoskin, Radhika Aiyappa‐Maudsley, Abdi Ghaffari, Sonal Varma, Andrew Green, Emad Rakha, Ian O. Ellis, Peter A. Greer, Stewart G. Martin
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Cancer Medicine, Vol 12, Iss 9, Pp 10908-10916 (2023)
Druh dokumentu: article
ISSN: 2045-7634
97080691
DOI: 10.1002/cam4.5802
Popis: Abstract Introduction The cytoskeletal protein ezrin is upregulated in many cancer types and is strongly associated with poor patient outcome. While the clinical and prognostic value of ezrin has been previously evaluated in breast cancer, most studies to date have been conducted in smaller cohorts (less than 500 cases) or have focused on specific disease characteristics. The current study is the largest of its kind to evaluate ezrin both at the protein and mRNA levels in early‐stage breast cancer patients using the Nottingham (n = 1094) and METABRIC (n = 1980) cohorts, respectively. Results High expression of ezrin was significantly associated with larger tumour size (p = 0.027), higher tumour grade (p
Databáze: Directory of Open Access Journals
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