| Autor: |
Howard William R., Abreu Velez Ana Maria, Howard Michael S. |
| Jazyk: |
English<br />Spanish; Castilian<br />French<br />Polish |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Nasza Dermatologia Online, Vol 2, Iss 3, Pp 113-117 (2011) |
| Druh dokumentu: |
article |
| ISSN: |
2081-9390 |
| Popis: |
Background. The immunopathogenesis of psoriasis is complex, and involves alterations in the innate immunologic system Case Report: A 57-year-old female was evaluated for the presence of rapidly appearing plaques on the knees and elbows. Methods: Skin biopsies for hematoxylin and eosin examination, as well as for direct immunofluorescence and immunohistochemistry analysis were performed. Results: H&E examination demonstrated classic features of psoriasis. Direct immunofluorescence revealed positive anti-corneal antibodies with several immunoglobulins, as well as positivity to upper and deep small dermal blood vessels. Immunohistochemistry revealed an increased expression of survivin, anti-human-ribosomal protein S6-p240, Topoisomerase II ά, cyclin D1, and Bcl-2 in lesional plaques. Conclusions: The pathobiology of psoriasis seems to involve a series of molecules involved in a complex interaction between the inflammation itself, cell cycle regulation, and ectopic expression of selected molecules. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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