Cut-off point of mature oocyte for routine clinical application of rescue IVM: a retrospective cohort study

Autor: Jianbo Wei, Zhongyu Luo, Xiyuan Dong, Huizi Jin, Lixia Zhu, Jihui Ai
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Ovarian Research, Vol 16, Iss 1, Pp 1-10 (2023)
Druh dokumentu: article
ISSN: 1757-2215
DOI: 10.1186/s13048-023-01294-z
Popis: Abstract Background The rescue in vitro mature(Rescue IVM) technique allows the use of immature oocytes collected in conventional COH to obtain more mature oocytes for fertilization through in vitro maturation. Some studies have shown that Rescue IVM could improve clinical outcomes in patients undergoing IVF/ICSI, but the effectiveness and the indications for the clinical application of this technique remain controversial. It remains to be studied whether Rescue IVM should be universally applied in all conventional IVF/ICSI cycles. Method This is a large retrospective cohort study that included a total of 22,135 female patients undergoing their first IVF treatment cycles. The effect of the number of mature oocytes(metaphaseII[MII]) on the cumulative live birth rate was investigated in a population with routine IVF/ICSI first. The receiver operating characteristic curve(ROC) analysis was used to explore the cut-off point of the number of MII affecting CLBR. Secondly, Patients undergoing ICSI with Rescue IVM were included in the analysis with those who underwent ICSI only during the same period, grouped according to the MII cut-off values. Multi-factor binary logistic regression and inverse probability weighting (IPW) were used to investigate whether Rescue IVM influenced the final cumulative live birth rate(CLBR). Results The CLBR increased with the number of MIIoocytes (P
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