Oleanolic acid improved intestinal immune function by activating and potentiating bile acids receptor signaling in E. coli-challenged piglets

Autor:	Chenyu Xue, Hongpeng Jia, Rujing Cao, Wenjie Cai, Weichen Hong, Jianing Tu, Songtao Wang, Qianzhi Jiang, Chongpeng Bi, Anshan Shan, Na Dong
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Bile acid receptors Enterotoxigenic Escherichia coli Intestinal innate immunity Oleanolic acid Animal culture SF1-1100 Veterinary medicine SF600-1100
Zdroj:	Journal of Animal Science and Biotechnology, Vol 15, Iss 1, Pp 1-19 (2024)
Druh dokumentu:	article
ISSN:	2049-1891
DOI:	10.1186/s40104-024-01037-0
Popis:	Abstract Background Infection with pathogenic bacteria during nonantibiotic breeding is one of the main causes of animal intestinal diseases. Oleanolic acid (OA) is a pentacyclic triterpene that is ubiquitous in plants. Our previous work demonstrated the protective effect of OA on intestinal health, but the underlying molecular mechanisms remain unclear. This study investigated whether dietary supplementation with OA can prevent diarrhea and intestinal immune dysregulation caused by enterotoxigenic Escherichia coli (ETEC) in piglets. The key molecular role of bile acid receptor signaling in this process has also been explored. Results Our results demonstrated that OA supplementation alleviated the disturbance of bile acid metabolism in ETEC-infected piglets (P
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/d96faf926a2d43a884f3cb3c3b0bd0c6 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.