Regioselective synthesis of C3 alkylated and arylated benzothiophenes

Autor: Harry J. Shrives, José A. Fernández-Salas, Christin Hedtke, Alexander P. Pulis, David J. Procter
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Nature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms14801
Popis: Benzothiophenes are common motifs in bioactive compounds, but selective functionalization at C3 is challenging. Here the authors report a method starting from benzothiophene S-oxides via an interrupted Pummerer reaction, giving access to a range of C3-alkylated and -arylated products.
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